Scopafungin, a crystalline endomycin component.

Scopafungin, a crystalline antibiotic produced by Streptomyces hygroscopicus var. enhygrus var. nova.

Scopafungin (U-29,479) is a crystalline, nonpolyenic antimicrobial agent obtained from the culture broth of Streptomyces hygroscopicus var. enhygrus var. nova UC-2397. Scopafungin inhibits, in vitro, a variety of pathogenic fungi, yeasts, and gram-positive bacteria.

Demalonyl derivatives of azalomycin F4 and scopafungin.

Desertomycin: purification and physical-chemical properties.

Desertomycin was isolated from Streptomyces macronensis Dietz sp. nov. UC 8271. Extensive spectroscopic work led us to place desertomycin in the macrocyclic lactone family which contains monazomycin, scopafungin, primycin, azalomycin F4a and niphithricins A and B. The apparent molecular formula was determined by fast atom bombardment mass spectroscopy to be C57H109NO24 (MW = 1,191). Mild acid h...

Diastereoselective Synthesis of Stable Phosphorus Yields by a Three-Component Reaction between Ph3P and Acetylenic Esters in the Presence of Hydrazine Derivatives

In this work, stable crystalline phosphorus yields are obtained in good yields from the 1:1:1 addition reactions between hydrazine derivatives and dialkyl acetylenedicarboxylates in the presence of triphenylphosphine at room temperature in dichloromethane. This synthetic method has merits of high yields, mild reaction conditions, and simple experimental and work-up conditions. The obtained yiel...

Hexaene H-85, a hexaene macrolide complex.

The hexaene macrolide antibiotics constitute the smallest group of the polyenes (12 ~ 1 5). Mediocidin, endomycin, hexaene H-85 and hexafungin each have a significant tetraene spectrum in addition to a hexaene spectrum (hexaene spectrum being predominant) and show high activity against fungi and moderate against Gram-positive bacteria. It was not possible to isolate the separate tetraene and he...